Veterans Health Library

Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, risperidone.

Warnings & Precautions

nafcillin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. naldemedineflibanserin increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Monitor naldemedine for potential adverse effects if coadministered with P-gp inhibitors. flibanserin increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. nevirapinenevirapine will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

How do I store and/or throw out this drug?

nevirapine will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nifedipinenifedipine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nifedipine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nisoldipinenisoldipine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nisoldipine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

What should I do if I miss a dose of Addyi?

nitrous oxidenitrous oxide and flibanserin both increase sedation. nitrous oxide and flibanserin both increase sedation. nizatidinenizatidine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nizatidine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. olanzapineolanzapine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. risperidone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

rucaparibrucaparib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

rucaparib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

• The pharmacology of flibanserin demonstrates a complex serotonin-dopamine interplay.
• The medication is not a substitute for addressing relationship or psychological factors.
• It is essential to evaluate contraindications before prescribing flibanserin.
• The drug's societal impact includes increased awareness of female sexual health.
• Use during pregnancy is contraindicated due to unknown risks.
• Flibanserin requires healthcare provider supervision due to its safety profile.
• Its effectiveness varies, necessitating personalized treatment approaches.
• Ongoing studies seek to expand understanding of its benefits and risks.
• The medication represents a milestone in female sexual medicine advancements.

scopolamine intranasalscopolamine intranasal and flibanserin both increase sedation.

Side effects of Addyi (flibanserin)

rifampinrifampin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifampin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifapentinerifapentine will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifapentine will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. risperidonerisperidone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. scopolamine intranasal and flibanserin both increase sedation.

selegilineselegiline will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Further information

pazopanib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pentamidinepentamidine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pentamidine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pentobarbitalpentobarbital will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Strong CYP3A4 inducers substantially decrease flibanserin systemic exposure.pentobarbital and flibanserin both increase sedation.

Dosing Considerations

pentobarbital will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenobarbitalphenobarbital will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenobarbital will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenytoinphenytoin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenytoin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Vyleesi (bremelanotide)

pilocarpinepilocarpine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pilocarpine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pimozidepimozide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, pimozide. pimozide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. selegiline will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

More about flibanserin

rabeprazolerabeprazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rabeprazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ranolazineranolazine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ranolazine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifabutin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. selegiline transdermal will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

sirolimusflibanserin increases levels of sirolimus by P-glycoprotein (MDR1) efflux transporter.

Mechanism of action

Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, olanzapine. olanzapine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. omeprazoleomeprazole will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. Coadministration of flibanserin with strong CYP2C19 inhibitors may increase flibanserin exposure and increase the risk of hypotension, syncope, and CNS depression.omeprazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. omeprazole will increase the level or effect of flibanserin by sexual enhancement pills affecting hepatic enzyme CYP2C19 metabolism.

Biochem/physiol Actions

orphenadrineorphenadrine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. orphenadrine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oxybutyninoxybutynin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oxybutynin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oxybutynin transdermal will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Approval Year

palbociclibpalbociclib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. palbociclib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. paroxetineparoxetine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. paroxetine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pazopanibpazopanib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increase monitoring of concentrations of drugs transported by P-gp that have a narrow therapeutic index if

• Clinical trials excluded women with many comorbidities (e.g., unstable medical conditions).
• Real-world effectiveness in broader populations may differ from trial results.
• Patient satisfaction with treatment can vary widely.
• Some women report significant improvement in sexual desire and distress.
• Others discontinue due to side effects or lack of meaningful benefit.
• Adherence to daily dosing is a challenge for some patients.
• The bedtime dosing schedule is intended to mitigate side effects like dizziness.
• Taking it with a high-fat meal can increase absorption and side effect risk.
• Should be taken on an empty stomach, at least 2 hours after a high-fat meal.

coadministered with flibanserin.sirolimus will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Overdose/Missed Dose

pravastatinpravastatin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pravastatin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. prednisoloneprednisolone will increase the level or effect of flibanserin by aldehyde dehydrogenase inhibition. prednisolone will increase the level or effect of flibanserin by aldehyde dehydrogenase inhibition. primaquineprimaquine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Storage Requirements

primaquine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. primidoneprimidone will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. primidone will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. progesterone micronizedprogesterone micronized will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. progesterone micronized will buy cenforce 120mg increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Does Addyi interact with foods or drinks?

propofolpropofol will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. propofol will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. quinineflibanserin increases levels of quinine by P-glycoprotein (MDR1) efflux transporter. Increase monitoring of concentrations of drugs transported by P-gp that have a narrow therapeutic index if coadministered with flibanserin.quinine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. flibanserin increases levels of quinine by P-glycoprotein (MDR1) efflux transporter.